Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications

  title={Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications},
  author={Jijun Chen},
  journal={Reviews in the Neurosciences},
  pages={269 - 280}
  • Jijun Chen
  • Published 1 April 2014
  • Biology
  • Reviews in the Neurosciences
Abstract Heme oxygenase (HO) was regarded as an enzyme to degrade heme in aging red blood cells; recent studies suggested HO might have other functions such as neuroprotection. HO degrades heme to produce carbon monoxide (CO), iron (Fe2+) and biliverdin, which is rapidly converted to bilirubin (BR). Three isoforms of HO were identified in the brain: inducible form (HO-1) and constitutive forms (HO-2 and HO-3). HO-1 and HO-2 may have different mechanisms to protect neurons from oxidative stress… 

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