Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications
@article{Chen2014HemeOI, title={Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications}, author={Jijun Chen}, journal={Reviews in the Neurosciences}, year={2014}, volume={25}, pages={269 - 280} }
Abstract Heme oxygenase (HO) was regarded as an enzyme to degrade heme in aging red blood cells; recent studies suggested HO might have other functions such as neuroprotection. HO degrades heme to produce carbon monoxide (CO), iron (Fe2+) and biliverdin, which is rapidly converted to bilirubin (BR). Three isoforms of HO were identified in the brain: inducible form (HO-1) and constitutive forms (HO-2 and HO-3). HO-1 and HO-2 may have different mechanisms to protect neurons from oxidative stress…
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