Heme oxygenase and the kidney.

  title={Heme oxygenase and the kidney.},
  author={Nathalie Hill-Kapturczak and S Chang and Anupam Agarwal},
  journal={DNA and cell biology},
  volume={21 4},
Heme plays a significant pathogenic role in several diseases involving the kidney. The cellular content of heme, derived either from the delivery of filtered heme proteins such as hemoglobin and myoglobin, or from the breakdown of ubiquitous intracellular heme proteins, is regulated via the heme oxygenase enzyme system. Heme oxygenases catalyze the rate-limiting step in heme degradation, resulting in the formation of iron, carbon monoxide, and biliverdin, which is subsequently converted to… CONTINUE READING
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