Heme oxygenase and the cardiovascular-renal system.

  title={Heme oxygenase and the cardiovascular-renal system.},
  author={Nader G Abraham and A. Kappas},
  journal={Free radical biology & medicine},
  volume={39 1},
Heme oxygenase (HO) has been shown to be important for attenuating the overall production of reactive oxygen species (ROS) through its ability to degrade heme and to produce carbon monoxide (CO), biliverdin/bilirubin, and the release of free iron. Excess free heme catalyzes the formation of ROS, which may lead to endothelial cell (EC) dysfunction as seen in numerous pathological conditions including hypertension and diabetes, as well as ischemia/reperfusion injury. The upregulation of HO-1 can… CONTINUE READING
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