Heme oxygenase and renal disease.

  title={Heme oxygenase and renal disease.},
  author={Tambi Jarmi and Anupam Agarwal},
  journal={Current hypertension reports},
  volume={11 1},
The cellular content of heme, derived from the breakdown of heme proteins, is regulated via the heme oxygenase (HO) enzyme system. HO catalyzes the rate-limiting step in heme degradation resulting in the formation of iron, carbon monoxide, and biliverdin. Recent studies have focused on the biologic effects of product(s) of this reaction, which have important antioxidant, antiapoptotic, anti-inflammatory, and cytoprotective properties. Two isoforms of the HO enzyme have been described: an… CONTINUE READING


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