Heme oxygenase and renal disease

@article{Jarmi2009HemeOA,
  title={Heme oxygenase and renal disease},
  author={Tambi Jarmi and A. Agarwal},
  journal={Current Hypertension Reports},
  year={2009},
  volume={11},
  pages={56-62}
}
  • Tambi Jarmi, A. Agarwal
  • Published 2009
  • Medicine
  • Current Hypertension Reports
  • The cellular content of heme, derived from the breakdown of heme proteins, is regulated via the heme oxygenase (HO) enzyme system. HO catalyzes the rate-limiting step in heme degradation resulting in the formation of iron, carbon monoxide, and biliverdin. Recent studies have focused on the biologic effects of product(s) of this reaction, which have important antioxidant, antiapoptotic, anti-inflammatory, and cytoprotective properties. Two isoforms of the HO enzyme have been described: an… CONTINUE READING
    79 Citations
    Cytoprotection behind heme oxygenase-1 in renal diseases.
    • 17
    Heme Oxygenase 1 as a Therapeutic Target in Acute Kidney Injury.
    • 60
    Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia.
    • 130
    Effect of heme oxygenase-1 on ochratoxin A-induced nephrotoxicity in mice.
    • 16
    Heme oxygenase-1 as a target for TGF-β in kidney disease.
    • 19
    Induction of Heme Oxygenase-1 Can Halt and Even Reverse Renal Tubule-Interstitial Fibrosis
    • 57
    • PDF
    Heme oxygenase activity as a determinant of the renal hemodynamic response to low-dose ANG II.
    • 8
    • PDF

    References

    SHOWING 1-10 OF 55 REFERENCES
    Heme oxygenase and the kidney.
    • 137
    The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury.
    • 233
    • PDF
    Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression.
    • A. Agarwal, H. Nick
    • Biology, Medicine
    • Journal of the American Society of Nephrology : JASN
    • 2000
    • 255
    Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues.
    • K. Nath
    • Chemistry, Medicine
    • Kidney international
    • 2006
    • 271
    Cytoprotective effects of heme oxygenase in acute renal failure.
    • 52
    The heme oxygenase system: a regulator of second messenger gases.
    • M. Maines
    • Chemistry, Medicine
    • Annual review of pharmacology and toxicology
    • 1997
    • 2,339
    Pro-oxidant and cytotoxic effects of circulating heme.
    • 523
    • PDF
    Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis.
    • 283
    • PDF