Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury.

@article{Zhu2008HemeOS,
  title={Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury.},
  author={Zhaowen Zhu and Anne T Wilson and M. Meleah Mathahs and Feng Wen and Kyle E. Brown and Bruce A. Luxon and Warren N. Schmidt},
  journal={Hepatology},
  year={2008},
  volume={48 5},
  pages={1430-9}
}
UNLABELLED Oxidative injury to hepatocytes occurs as a result of hepatitis C virus (HCV) infection and replication. Modulation of host cell antioxidant enzymes such as heme oxygenase-1 (HO-1) may be useful therapeutically to minimize cellular injury, reduce viral replication, and attenuate liver disease. In this report, we evaluated the effects of HO-1 overexpression on HCV replication and hepatocellular injury. Full-length (FL) (Con1) or nonstructural (NS) replicons (I 389 NS3-3') were… CONTINUE READING