Heme oxygenase-1 protects against Alzheimer's amyloid-β1-42-induced toxicity via carbon monoxide production

@inproceedings{Hettiarachchi2014HemeOP,
  title={Heme oxygenase-1 protects against Alzheimer's amyloid-β1-42-induced toxicity via carbon monoxide production},
  author={Nishani T. Hettiarachchi and Mark L Dallas and Moza Al-Owais and Handsel Griffiths and Nigel M Hooper and Jason L. Scragg and John P Boyle and Chris S Peers},
  booktitle={Cell Death and Disease},
  year={2014}
}
Heme oxygenase-1 (HO-1), an inducible enzyme up-regulated in Alzheimer’s disease, catabolises heme to biliverdin, Fe2+ and carbon monoxide (CO). CO can protect neurones from oxidative stress-induced apoptosis by inhibiting Kv2.1 channels, which mediates cellular K+ efflux as an early step in the apoptotic cascade. Since apoptosis contributes to the neuronal loss associated with amyloid β peptide (Aβ) toxicity in AD, we investigated the protective effects of HO-1 and CO against Aβ1-42 toxicity… CONTINUE READING