Heme oxygenase-1 modulates microRNA expression in cultured astroglia: implications for chronic brain disorders.

@article{Lin2015HemeOM,
  title={Heme oxygenase-1 modulates microRNA expression in cultured astroglia: implications for chronic brain disorders.},
  author={Shih-Hsiung Lin and Wei Song and Marisa Cressatti and Hillel Zukor and Eugenia Wang and Hyman M. Schipper},
  journal={Glia},
  year={2015},
  volume={63 7},
  pages={1270-84}
}
BACKGROUND Over-expression of the heme-degrading enzyme, heme oxygenase-1 (HO-1) promotes iron deposition, mitochondrial damage, and autophagy in astrocytes and enhances the vulnerability of nearby neuronal constituents to oxidative injury. These neuropathological features and aberrant brain microRNA (miRNA) expression patterns have been implicated in the etiopathogeneses of various neurodevelopmental and aging-related neurodegenerative disorders. OBJECTIVE To correlate glial HO-1… CONTINUE READING
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