Heme oxygenase-1 mediates oxidative stress and apoptosis in coxsackievirus B3-induced myocarditis.

@article{Ursu2014HemeOM,
  title={Heme oxygenase-1 mediates oxidative stress and apoptosis in coxsackievirus B3-induced myocarditis.},
  author={Oana N. Ursu and Martina Sauter and Nicole Ettischer and Reinhard Kandolf and Karin Klingel},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2014},
  volume={33 1},
  pages={52-66}
}
BACKGROUND Heme oxygenase-1 (HO-1), which is suggested to play a role in defending the organism against oxidative stress-mediated injuries, can be induced by diverse factors including viruses and iron. As coxsackievirus B3 (CVB3)-infected SWR/J mice susceptible for chronic myocarditis were found to have a significant iron incorporation and HO-1 upregulation in the myocardium, we aimed to investigate the molecular interplay between HO-1 expression and iron homeostasis in the outcome of viral… CONTINUE READING