Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers.

@article{Uc2012HemeOI,
  title={Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers.},
  author={Aliye Uc and Xiaoyan Zhu and Brett A Wagner and Garry R Buettner and Dj Van Den Berg},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2012},
  volume={54 4},
  pages={
          471-6
        }
}
OBJECTIVES Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain, fever, and inflammation. Long-term use of these drugs is associated with significant gastric injury. Activated neutrophils and oxidative stress seem to play a significant role in NSAID-induced gastric mucosal damage. The objective of our study is to examine the protective effects of an antioxidant and anti-inflammatory enzyme, heme oxygenase-1 (HO-1), in NSAID-induced gastric injury. METHODS… CONTINUE READING
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