Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells.

@article{Pulkkinen2011HemeO1,
  title={Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells.},
  author={Kati H Pulkkinen and Seppo Yl{\"a}-Herttuala and A L Levonen},
  journal={Free radical biology & medicine},
  year={2011},
  volume={51 11},
  pages={2124-31}
}
Heme oxygenase 1 (HO-1) is a stress-inducible enzyme that degrades redox-active heme-producing biliverdin, carbon monoxide, and Fe(2+). It protects cells under various stress conditions and mediates anti-inflammatory and vasodilatory effects in the endothelium. The expression of HMOX1, the HO-1 gene, is highly inducible and its transcriptional regulation is complex. HMOX1 is induced by various proinflammatory stimuli via NF-κB in human endothelial cells, but functional NF-κB-binding elements… CONTINUE READING