Heme oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine.

  title={Heme oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine.},
  author={Kati Erdmann and Belinda W. Y. Cheung and Stephan Immenschuh and Henning Schr{\"o}der},
  journal={Biochemical and biophysical research communications},
  volume={368 4},
The sulfur compound and dietary supplement S-adenosylmethionine (SAM) has been reported to have cytoprotective and antioxidant properties. However, the underlying mechanisms remain unresolved. The present study investigates the effect of SAM on the expression of the antioxidant stress proteins heme oxygenase-1 (HO-1) and ferritin in endothelial cells. Induction of the HO-1/ferritin-system leads to protection of tissues against several inflammatory stimuli. SAM increased the protein and mRNA… CONTINUE READING


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