Heme oxygenase-1 inhibits pro-oxidant induced hypertrophy in HL-1 cardiomyocytes.

@article{Brunt2009HemeOI,
  title={Heme oxygenase-1 inhibits pro-oxidant induced hypertrophy in HL-1 cardiomyocytes.},
  author={Keith R Brunt and Matthew R S Tsuji and Joyce H Y Lai and Robert T Kinobe and William Durante and William C. Claycomb and C. A. Ward and Luis Gabriel Melo},
  journal={Experimental biology and medicine},
  year={2009},
  volume={234 5},
  pages={582-94}
}
AIMS Reactive oxygen species (ROS) activate multiple signaling pathways involved in cardiac hypertrophy. Since HO-1 exerts potent antioxidant effects, we hypothesized that this enzyme inhibits ROS-induced cardiomyocyte hypertrophy. METHODS HL-1 cardiomyocytes were transduced with an adenovirus constitutively expressing HO-1 (AdHO-1) to increase basal HO-1… CONTINUE READING