Heme oxygenase-1 inhibition prevents intimal hyperplasia enhancing nitric oxide-dependent apoptosis of vascular smooth muscle cells.

Abstract

Heme oxygenase-1 (HO-1, encoded by the HMOX1 gene) and inducible nitric oxide synthase (iNOS) have been implicated in vascular disease; however the role of these genes remains unclear. Therefore, we studied the mechanism by which iNOS-derived nitric oxide (NO) affects the intimal hyperplasia (IH) formation in relation to HO-1. We show, in a model of balloon… (More)

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@article{Cerrito2011HemeOI, title={Heme oxygenase-1 inhibition prevents intimal hyperplasia enhancing nitric oxide-dependent apoptosis of vascular smooth muscle cells.}, author={Maria Grazia Cerrito and Alessandra Scagliarini and Alberto Froio and Angela Liloia and Marco Busnelli and Roberto Giovannoni and Leo Edmond Otterbein and Lara Mainetti and Matteo Villa and Fritz Heintz Bach and Biagio Eugenio Leone and Giorgio Maria Biasi and Marialuisa Lavitrano}, journal={Biological & pharmaceutical bulletin}, year={2011}, volume={34 8}, pages={1204-14} }