• Corpus ID: 40683360

Heme oxygenase-1 induction through p 38 MAPK / Nrf 2 activation by ethanol extract of Artemisia capillaries inhibits LPS-activated iNOS , COX-2 , and HMGB 1 in RAW 264 . 7 cells

  title={Heme oxygenase-1 induction through p 38 MAPK / Nrf 2 activation by ethanol extract of Artemisia capillaries inhibits LPS-activated iNOS , COX-2 , and HMGB 1 in RAW 264 . 7 cells},
  author={Hee Sook Kim and Eun Jung Park and Young min Kim and Sang Won Park and Hye Jung Kim and Jae Heun Lee and Ki Churl Chang},
Heme oxygenase-1 (HO-1) negatively regulates inflammatory cytokines in lipopolysaccharide (LPS)-activated RAW 264.7 cells. The purpose of the study was to know whether anti-inflammatory effect of the extract of Artemisia capillaries (EAC) is responsible for HO-1 protein expression in RAW264.7 cells. EAC increased HO-1 expression in a time and concentration-dependent manner and inhibited the expression of iNOS (NO) and COX-2 (PGE2), and release of high mobility group box 1 (HMGB1) in LPS… 

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