Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats.

@article{Nicolai2009HemeOI,
  title={Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats.},
  author={Angelique Nicolai and Ming Li and Dong Hyun Kim and Stephen J Peterson and Luca Vanella and Vincenzo Positano and Amalia Gastaldelli and Rita Rezzani and Luigi Fabrizio Rodella and George Drummond and Claudia Kusmic and Antonio L'Abbate and A. Kappas and Nader G Abraham},
  journal={Hypertension},
  year={2009},
  volume={53 3},
  pages={508-15}
}
Obesity-associated inflammation causes insulin resistance. Obese adipose tissue displays hypertrophied adipocytes and increased expression of the cannabinoid-1 receptor. Cobalt protoporphyrin (CoPP) increases heme oxygenase-1 (HO-1) activity, increasing adiponectin and reducing inflammatory cytokines. We hypothesize that CoPP administration to Zucker diabetic fat (ZDF) rats would improve insulin sensitivity and remodel adipose tissue. Twelve-week-old Zucker lean and ZDF rats were divided into 4… CONTINUE READING