Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate.

@article{Oberle2002HemeOI,
  title={Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate.},
  author={Stefanie Oberle and Aida Abate and Nina Grosser and H. Vreman and Phyllis A. Dennery and Heinz T Schneider and Dirk Stalleicken and Henning Schr{\"o}der},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={290 5},
  pages={1539-44}
}
The organic nitrate pentaerythrityl tetranitrate (PETN) is known to exert long-term antioxidant and antiatherogenic effects by as yet unidentified mechanisms. In cultured endothelial cells derived from human umbilical vein, the active PETN metabolite PETriN (0.01-1 mM) increased heme oxygenase (HO)-1 mRNA and protein levels in a concentration-dependent… CONTINUE READING