Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation.

@article{Pileggi2001HemeOI,
  title={Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation.},
  author={Antonello Pileggi and Ruth Damaris Molano and Thierry Berney and Pierre Cattan and Caterina Vizzardelli and Robert C. Oliver and C. Fraker and Camillo Ricordi and Ricardo Luis Pastori and Fritz Heintz Bach and Luca Alessandro Inverardi},
  journal={Diabetes},
  year={2001},
  volume={50 9},
  pages={1983-91}
}
Transplantation of islets of Langerhans represents a viable therapeutic approach for the treatment of type 1 diabetes. Unfortunately, transplanted islets are susceptible to allogeneic recognition and rejection, recurrence of autoimmunity, and destruction by local inflammation at the site of implantation. The last of these phenomena might not only result in functional impairment and death of islet cells but could also contribute to amplifying the subsequent specific immune response. Induction of… CONTINUE READING