Heme oxygenase-1 increases endothelial progenitor cells.

  title={Heme oxygenase-1 increases endothelial progenitor cells.},
  author={Ben Juan Wu and Robyn G. Midwinter and Carlos Cassano and Konstanze Beck and Yutang Wang and Dechaboon Changsiri and Jennifer R. Gamble and Roland Stocker},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={29 10},
OBJECTIVE Induction of heme oxygenase-1 (HO-1) protects against atherosclerotic disease in part by promoting reendothelialization. As endothelial progenitor cells (EPCs) contribute to reendothelialization, we examined the role of HO-1 on bone marrow and circulating EPCs. METHODS AND RESULTS In a rabbit model of aortic balloon injury, pharmacological induction of HO-1 enhanced reendothelialization at sites with and without adjacent blood vessels, the latter indicative of a contribution by EPCs… CONTINUE READING


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