Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis.

@article{Schluesener2000HemeOI,
  title={Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis.},
  author={Hermann Josef Schluesener and Karin Seid},
  journal={Journal of neuroimmunology},
  year={2000},
  volume={110 1-2},
  pages={114-20}
}
The enzyme heme oxygenase-1 (HO-1) is reducing heme to the gaseous mediator carbon monoxide, to iron and the antioxidant biliverdin. The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates. Further, carbon monoxide (CO) is a regulator of cGMP synthesis, of NO-synthetases and cyclooxygenases, thereby indirectly modulating reactive processes. Here we report expression of HO-1 in rat experimental autoimmune encephalomyelitis (EAE) and… CONTINUE READING
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