Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim

@article{Schipper2010HemeOI,
  title={Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim},
  author={Hyman M. Schipper},
  journal={Journal of Neural Transmission},
  year={2010},
  volume={118},
  pages={381-387}
}
Heme oxygenase-1 (HO-1), a 32 kDa stress protein mediating the degradation of heme to ferrous iron, carbon monoxide and biliverdin/bilirubin, has been implicated in the pathogenesis of Alzheimer disease (AD) and other aging-related neurodegenerative disorders. In AD and mild cognitive impairment (MCI), immunoreactive HO-1 protein is over-expressed in astrocytes and neurons of the hippocampus and cerebral cortex and co-localizes to neurofibrillary tangles, senile plaques and corpora amylacea… CONTINUE READING