Heme oxygenase-1 gene promoter polymorphism and the risk of pediatric nonalcoholic fatty liver disease

@article{Chang2015HemeOG,
  title={Heme oxygenase-1 gene promoter polymorphism and the risk of pediatric nonalcoholic fatty liver disease},
  author={P-F Chang and Y-C Lin and Kuo-Yu Liu and S-J Yeh and Yen-Hsuan Ni},
  journal={International Journal of Obesity},
  year={2015},
  volume={39},
  pages={1236-1240}
}
Background and objectives:Oxidative stress and the insulin-resistant state are thought to be key components in the pathogenesis of pediatric nonalcoholic fatty liver disease (NAFLD). Heme oxygenase (HO) is important in the defense against oxidative stress. This study aimed to assess the association of HO-1 gene promoter polymorphism and insulin resistance with NAFLD among obese children.Methods:A total of 101 obese children aged 6–17 years were recruited. Anthropometric, serum biochemical… CONTINUE READING