Heme oxygenase-1 gene expression by a glutathione depletor, phorone, mediated through AP-1 activation in rats.

@article{Oguro1996HemeOG,
  title={Heme oxygenase-1 gene expression by a glutathione depletor, phorone, mediated through AP-1 activation in rats.},
  author={Takiko Oguro and Matsuhiko Hayashi and Satoshi Numazawa and Katsuaki Asakawa and Takayuki Yoshida},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={221 2},
  pages={259-65}
}
This study shows that induction of heme oxygenase-1 (HO-1) gene expression by a glutathione (GSH) depletor, phorone, is inhibited by cycloheximide pretreatment and involves changes in c-jun, not c-fos, mRNA. Buthionine sulfoximine (BSO) enhanced markedly both c-jun and HO-1 gene expression evoked by phorone. Phorone dramatically increased AP-1 binding activity, which was blocked by unlabeled AP-1 oligonucleotide and abolished by anit-Jun antibodies, but not anti-Fos antibodies. In addition… CONTINUE READING