Heme oxygenase-1 gene enhancer manifests silencing activity in a chromatin environment prior to oxidative stress.

@article{Dohi2006HemeOG,
  title={Heme oxygenase-1 gene enhancer manifests silencing activity in a chromatin environment prior to oxidative stress.},
  author={Yoshihiro Dohi and Jawed Alam and Masao Yoshizumi and Jiying Sun and Kazuhiko Igarashi},
  journal={Antioxidants & redox signaling},
  year={2006},
  volume={8 1-2},
  pages={60-7}
}
The expression of heme oxygenase-1 (HO-1) is regulated by E1 and E2 enhancers, both of which contain multiple Maf recognition elements (MAREs). In living cells, MAREs are bound by Bach1/MafK heterodimers, hence maintaining a quiescent state of the HO-1 gene (hmox-1). However, in transient transfection assays, they act as transcriptional enhancers. Therefore MAREs may manifest their function only in a chromatin environment. By using NIH3T3 cell pools stably transfected with EGFP reporter genes… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…