Heme oxygenase-1 expression in disease states.

  title={Heme oxygenase-1 expression in disease states.},
  author={Jessy S Deshane and Marcienne M Wright and Anupam Agarwal},
  journal={Acta biochimica Polonica},
  volume={52 2},
Heme oxygenase-1 (HO-1) is an enzyme which catalyzes the rate-limiting step in heme degradation resulting in the formation of iron, carbon monoxide and biliverdin, which is subsequently converted to bilirubin by biliverdin reductase. The biological effects exerted by the products of this enzymatic reaction have gained much attention. The anti-oxidant, anti-inflammatory and cytoprotective functions associated with HO-1 are attributable to one or more of its degradation products. Induction of HO… CONTINUE READING