Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo.

@article{Motterlini1998HemeOC,
  title={Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo.},
  author={Roberto Motterlini and Armando Gonzales and Roberta Foresti and J. E. Clark and Colin J. Green and Robert M. Winslow},
  journal={Circulation research},
  year={1998},
  volume={83 5},
  pages={
          568-77
        }
}
The enzyme heme oxygenase, which exists in inducible (HO-1) and constitutive (HO-2) isoforms, catalyzes the degradation of heme to biliverdin and CO in mammalian tissues. CO has been implicated in the control of vascular tone in a manner similar to that for NO. In the present study, we investigated the contribution of the heme oxygenase/CO pathway to the modulation of acute hypertensive responses in vivo induced by (1) alphaalphaHb, a chemically modified hemoglobin known to scavenge NO, and (2… Expand
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