Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors.

@article{Cao2008HemeOD,
  title={Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors.},
  author={Yu-an Cao and Amy J. Wagers and Holger Karsunky and Hui Zhao and Robert Reeves and Ronald J Wong and David K. Stevenson and Irving L Weissman and Christopher H. Contag},
  journal={Blood},
  year={2008},
  volume={112 12},
  pages={4494-502}
}
An effective response to extreme hematopoietic stress requires an extreme elevation in hematopoiesis and preservation of hematopoietic stem cells (HSCs). These diametrically opposed processes are likely to be regulated by genes that mediate cellular adaptation to physiologic stress. Herein, we show that heme oxygenase-1 (HO-1), the inducible isozyme of heme degradation, is a key regulator of these processes. Mice lacking one allele of HO-1 (HO-1(+/-)) showed accelerated hematopoietic recovery… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

and reveal endothelial niches for stem cells

  • R Song, RS Mahidhara, Z Zhou
  • 2005

Similar Papers

Loading similar papers…