Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders.

@article{Gill2014HemeOD,
  title={Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders.},
  author={Alexander J Gill and Colleen Elizabeth Kovacsics and Stephanie A. Cross and Patricia J. Vance and Lorraine L. Kolson and Kelly L Jordan-Sciutto and Benjamin B. Gelman and Dennis L Kolson},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 10},
  pages={
          4459-72
        }
}
Heme oxygenase-1 (HO-1) is an inducible, detoxifying enzyme that is critical for limiting oxidative stress, inflammation, and cellular injury within the CNS and other tissues. Here, we demonstrate a deficiency of HO-1 expression in the brains of HIV-infected individuals. This HO-1 deficiency correlated with cognitive dysfunction, HIV replication in the CNS, and neuroimmune activation. In vitro analysis of HO-1 expression in HIV-infected macrophages, a primary CNS HIV reservoir along with… CONTINUE READING

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