Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide.

@article{True2007HemeOD,
  title={Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide.},
  author={Andrea L. True and Michelle Olive and Manfred Boehm and Hong San and Randal J. Westrick and Nalini Raghavachari and Xiuli Xu and Edward G Lynn and Michael N. Sack and Peter J. Munson and Mark T Gladwin and Elizabeth G. Nabel},
  journal={Circulation research},
  year={2007},
  volume={101 9},
  pages={893-901}
}
Heme oxygenase (HO)-1 (encoded by Hmox1) catalyzes the oxidative degradation of heme to biliverdin and carbon monoxide. HO-1 is induced during inflammation and oxidative stress to protect tissues from oxidative damage. Because intravascular thrombosis forms at sites of tissue inflammation, we hypothesized that HO-1 protects against arterial thrombosis during oxidant stress. To investigate the direct function of HO-1 on thrombosis, we used photochemical-induced vascular injury in Hmox1-/- and… CONTINUE READING

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