Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries.

@article{Tulis2001HemeOA,
  title={Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries.},
  author={David A Tulis and William Durante and Kelly J. Peyton and Alida J. Evans and Andrew I. Schafer},
  journal={Atherosclerosis},
  year={2001},
  volume={155 1},
  pages={113-22}
}
The heme oxygenase-1 (HO-1) system of heme catabolism has been proposed to exert protective actions upon the cardiovascular system. This investigation examined the influence of HO-1 induction on vascular remodeling following arterial injury. Rats were subjected to left carotid artery (LCA) balloon injury following pre-treatment with either vehicle, the HO-1 inducer hemin (50 mg/kg, SC), or concomitant treatment with hemin and the HO-1 inhibitor tin-protoporphyrin IX (SnPP-IX; 50 micromol/kg, IP… CONTINUE READING