Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections.

@article{Cuadrado2008HemeOA,
  title={Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections.},
  author={Antonio Cuadrado and Ana Isabel Morcuende Rojo},
  journal={Current pharmaceutical design},
  year={2008},
  volume={14 5},
  pages={
          429-42
        }
}
Heme oxygenase-1 (HO-1) catalyzes the degradation of heme to generate carbon monoxide, biliverdin and free iron. Increased HO-1 levels constitute an anatomopathological feature of many neurological diseases, such as neurodegenerative disorders and brain infections, which correlate with exacerbated oxidative stress and inflammation. It is generally accepted that the elevated HO-1 levels represent an attempt to restore redox homeostasis and to down-modulate inflammation. However, experimental… CONTINUE READING
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