Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota.

@article{Onyiah2014HemeOA,
  title={Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota.},
  author={Joseph C. Onyiah and Shehzad Zafar Sheikh and Nitsan Maharshak and Leo E Otterbein and Scott Eric Plevy},
  journal={Gut microbes},
  year={2014},
  volume={5 2},
  pages={220-4}
}
Heme oxygenase-1 (HO-1) and its enzymatic by-product carbon monoxide (CO) have emerged as important regulators of acute and chronic inflammation. Mechanisms underlying their anti-inflammatory effects are only partially understood. In this addendum, we summarize current understanding of the role of the HO-1/CO pathway in regulation of intestinal inflammation… CONTINUE READING