Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption.

@article{Zwerina2005HemeO1,
  title={Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption.},
  author={Jochen Zwerina and Sotiria Tzima and Silvia Hayer and Kurt Redlich and Oskar Hoffmann and Beatrice Hanslik-Schnabel and Josef S Smolen and George Kollias and Georg Schett},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 14},
  pages={
          2011-3
        }
}
Heme oxygenase 1 (HO-1) plays an important role in vascular disease, transplantation, and inflammation. In animal models of acute and chronic inflammation, induction of HO-1 has anti-inflammatory and cytoprotective properties. Since inflammation is an important trigger of osteoclastogenesis, we hypothesized that HO-1 might influence osteoclastogenesis. We investigated the effects of induction of HO-1 on osteoclast formation in vitro and in vivo. Furthermore, we addressed the role of HO-1 in… CONTINUE READING

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  • M. P. Soares, M. P. Seldon, +4 authors Tsui
  • J. Immunol
  • 2004
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