Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues.

@article{Nath2006HemeOA,
  title={Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues.},
  author={Karl A Nath},
  journal={Kidney international},
  year={2006},
  volume={70 3},
  pages={
          432-43
        }
}
Heme oxygenase (HO) is the rate-limiting enzyme in the degradation of heme, converting heme to biliverdin, during which iron is released and carbon monoxide (CO) is emitted; biliverdin is subsequently converted to bilirubin by biliverdin reductase. At least two isozymes possess HO activity: HO-1 represents the isozyme induced by diverse stressors, including ischemia, nephrotoxins, cytokines, endotoxin, oxidants, and vasoactive substances; HO-2 is the constitutive, glucocorticoid-inducible… CONTINUE READING
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