Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.

@article{Salerno2017HemeOA,
  title={Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.},
  author={L. Salerno and G. Romeo and Maria N. Modica and E. Amata and Valeria Sorrenti and Ignazio Barbagallo and V. Pittal{\`a}},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={142},
  pages={
          163-178
        }
}
Heme oxygenase-1 (HO-1) is the enzyme catalyzing the rate-limiting oxidative degradation of cellular heme into free iron, carbon monoxide (CO), and biliverdin, which is then rapidly converted into bilirubin. By means of these catabolic end-products and by removal of pro-oxidant heme, HO-1 exerts antioxidant, antiapoptotic, and immune-modulating effects, leading to overall cytoprotective and beneficial functions in mammalian cells. Therefore, HO-1 is considered a survival molecule in various… Expand
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