Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy.

  title={Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy.},
  author={Stefan W. Ryter and Augustine M. K. Choi},
  journal={American journal of respiratory cell and molecular biology},
  volume={41 3},
Heme oxygenase-1 (HO-1), a ubiquitous inducible stress-response protein, serves a major metabolic function in heme turnover. HO activity cleaves heme to form biliverdin-IXalpha, carbon monoxide (CO), and iron. Genetic experiments have revealed a central role for HO-1 in tissue homeostasis, protection against oxidative stress, and in the pathogenesis of disease. Four decades of research have witnessed not only progress in elucidating the molecular mechanisms underlying the regulation and… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 101 extracted citations

Heme oxygenase-1 as a target for drug discovery.

Antioxidants & redox signaling • 2014
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…