Heme oxygenase: evolution, structure, and mechanism.

  title={Heme oxygenase: evolution, structure, and mechanism.},
  author={Angela Wilks},
  journal={Antioxidants & redox signaling},
  volume={4 4},
  • Angela Wilks
  • Published 2002 in Antioxidants & redox signaling
Heme oxygenase has evolved to carry out the oxidative cleavage of heme, a reaction essential in physiological processes as diverse as iron reutilization and cellular signaling in mammals, synthesis of essential light-harvesting pigments in cyanobacteria and higher plants, and the acquisition of iron by bacterial pathogens. In all of these processes, heme oxygenase has evolved a similar structural and mechanistic scaffold to function within seemingly diverse physiological pathways. The heme… CONTINUE READING


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