Heme oxygenase: colors of defense against cellular stress.

  title={Heme oxygenase: colors of defense against cellular stress.},
  author={Leo E Otterbein and Augustine M. K. Choi},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={279 6},
The discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its functional role in the pathogenesis of a wide spectrum of biological and pathological processes. At that time, the novel concept that an endogenous production of a gaseous substance such as nitric oxide can impart such diverse and potent cellular effects proved to be very fruitful in enhancing our understanding of many disease processes including lung disorders. Interestingly, we have known for a longer… CONTINUE READING
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