Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance

@article{Ryter2002HemeOM,
  title={Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance},
  author={Stefan W. Ryter and Leo E Otterbein and Danielle E Morse and Augustine M. K. Choi},
  journal={Molecular and Cellular Biochemistry},
  year={2002},
  volume={234},
  pages={249-263}
}
Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as constitutive (HO-2, HO-3) and inducible isoforms (HO-1), the latter which responds to regulation by multiple stress-stimuli. HO-1 confers protection in vitro and in vivo against oxidative cellular stress. Although the redox active compounds that are generated from HO activity (i.e. iron, biliverdin-IXα, and bilirubin-IX… CONTINUE READING
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Mitogen activated protein kinase ( MAPK ) pathway regulates heme oxygenase - 1 gene expression by hypoxia in vascular cells

  • S Ryter, S Xi, AM Choi
  • Antioxid Redox Signal :
  • 2002

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