Heme modulates intestinal epithelial cell activation: involvement of NADPHox-derived ROS signaling.

@article{BarcellosdeSouza2013HemeMI,
  title={Heme modulates intestinal epithelial cell activation: involvement of NADPHox-derived ROS signaling.},
  author={Pedro Barcellos-de-Souza and Jo{\~a}o Alfredo de Moraes and Julio Cesar M de-Freitas-Junior and Jose Andr{\'e}s Morgado-D{\'i}az and Christina Barja-Fidalgo and Maria Augusta Arruda},
  journal={American journal of physiology. Cell physiology},
  year={2013},
  volume={304 2},
  pages={
          C170-9
        }
}
In many gut chronic inflammatory conditions, intestinal epithelium (IE) is deprived of the protection of the mucus secreted by IE-specialized cells. In these events, bleeding and subsequent lysis of erythrocytes are common. This may lead to the release of high amounts of heme in the intestinal lumen, which interacts with IE. Previous works from our group have shown that heme itself is a proinflammatory molecule, activating a number of phlogistic signaling events in a nicotinamide adenine… CONTINUE READING

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