Heme is involved in microRNA processing

  title={Heme is involved in microRNA processing},
  author={Michael Faller and Michio Matsunaga and Sheng Yin and Joseph A Loo and Feng Guo},
  journal={Nature Structural &Molecular Biology},
MicroRNAs (miRNAs) regulate the expression of a large number of protein-coding genes. Their primary transcripts (pri-miRNAs) have to undergo multiple processing steps to reach the functional form. Little is known about how the processing of miRNAs is modulated. Here we show that the RNA-binding protein DiGeorge critical region-8 (DGCR8), which is essential for the first processing step, is a heme-binding protein. The association with heme promotes dimerization of DGCR8. The heme-bound DGCR8… CONTINUE READING
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