Heme is an effector molecule for iron-dependent degradation of the bacterial iron response regulator (Irr) protein.

@article{Qi1999HemeIA,
  title={Heme is an effector molecule for iron-dependent degradation of the bacterial iron response regulator (Irr) protein.},
  author={Zhenhao Qi and Iqbal Hamza and Mark R O'Brian},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 23},
  pages={
          13056-61
        }
}
The bacterial iron response regulator (Irr) protein mediates iron-dependent regulation of heme biosynthesis. Pulse-chase and immunoprecipitation experiments showed that Irr degraded in response to 6 microM iron with a half-life of approximately 30 min and that this regulated stability was the principal determinant of control by iron. Irr contains a heme regulatory motif (HRM) near its amino terminus. A role for heme in regulation was implicated by the retention of Irr in heme synthesis mutants… CONTINUE READING

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Metal Ions in Gene Regulation (Chapman

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1 Excerpt

Biosynthesis of Heme and Chlorophylls

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