Heme-iron increases levels of AP65-mediated adherence by Trichomonas vaginalis.

@article{Alderete2004HemeironIL,
  title={Heme-iron increases levels of AP65-mediated adherence by Trichomonas vaginalis.},
  author={Jos{\'e} Fernando Alderete and Jenny L. Nguyen and Vasanthakrishna Mundodi and Michael W. Lehker},
  journal={Microbial pathogenesis},
  year={2004},
  volume={36 5},
  pages={
          263-71
        }
}
Trichomonas vaginalis is a protozoan responsible for the number one, non-viral sexually transmitted disease. Surface proteins (AP65, AP51, AP33 and AP23) mediate adherence to vaginal epithelial cells (VECs). Iron increases growth of trichomonads and synthesis and surface placement of adhesins. We observed by immunofluorescence using monoclonal antibody (mAb) 12G4 the placement of AP65 on surfaces of trichomonads supplemented with hemoglobin or hemin as a source of iron. We, therefore, tested… CONTINUE READING
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