Heme enzymes. Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase.


Heme enzymes activate oxygen through formation of transient iron-oxo (ferryl) intermediates of the heme iron. A long-standing question has been the nature of the iron-oxygen bond and, in particular, the protonation state. We present neutron structures of the ferric derivative of cytochrome c peroxidase and its ferryl intermediate; these allow direct… (More)
DOI: 10.1126/science.1254398


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