Heme concentration dependence and metalloporphyrin inhibition of the system I and II cytochrome c assembly pathways.

@article{RichardFogal2007HemeCD,
  title={Heme concentration dependence and metalloporphyrin inhibition of the system I and II cytochrome c assembly pathways.},
  author={Cynthia L Richard-Fogal and Elaine R Frawley and Robert E Feissner and Robert G. Kranz},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 2},
  pages={455-63}
}
Studies have indicated that specific heme delivery to apocytochrome c is a critical feature of the cytochrome c biogenesis pathways called system I and II. To determine directly the heme requirements of each system, including whether other metal porphyrins can be incorporated into cytochromes c, we engineered Escherichia coli so that the natural system I (ccmABCDEFGH) was deleted and exogenous porphyrins were the sole source of porphyrins (Delta hemA). The engineered E. coli strains that… CONTINUE READING
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