Heme as trigger and target for trioxane-containing antimalarial drugs.


Heme is not only just the binding site responsible for oxygen transport by hemoglobin, but it is also the prosthetic group of many different heme-containing enzymes, such as cytochromes P450, peroxidases, catalase, and several proteins involved in electron transfer. Heme plays a key role in the mechanism of action of many different antimalarial drugs. In… (More)
DOI: 10.1021/ar100070k


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