Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors

@article{Amata2017HemeOD,
  title={Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors},
  author={E. Amata and A. Marrazzo and Maria Dichiara and M. Modica and L. Salerno and O. Prezzavento and G. Nastasi and A. Rescifina and G. Romeo and V. Pittal{\`a}},
  journal={ChemMedChem},
  year={2017},
  volume={12}
}
Due to increasing interest in the field of heme oxygenases (HOs), we built a ligand database called HemeOxDB that includes the entire set of known HO‐1 and HO‐2 inhibitors, resulting in more than 400 compounds. The HemeOxDB is available online at http://www.researchdsf.unict.it/hemeoxdb/, and having a robust search engine allows end users to build complex queries, sort tabulated results, and generate color‐coded two‐ and three‐dimensional graphs. This database will grow to be a tool for the… Expand
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26 Citations
Background Citations
3
Methods Citations
1

26 Citations

Citation Type

Citation Type

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Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application.
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Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors.
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Immune Modulation by Inhibitors of the HO System
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Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region.
Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.
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References

SHOWING 1-10 OF 54 REFERENCES
Evaluation of Imidazole‐Based Compounds as Heme Oxygenase‐1 Inhibitors
  • 24
A focus on heme oxygenase-1 (HO-1) inhibitors.
  • 53
Inhibitors of the heme oxygenase - carbon monoxide system: on the doorstep of the clinic?
  • 51
Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.
  • 35
coral Software: QSAR for Anticancer Agents
  • 23
  • PDF
Development of a Sigma‐2 Receptor affinity filter through a Monte Carlo based QSAR analysis
  • A. Rescifina, Giuseppe Floresta, +5 authors E. Amata
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2017
  • 41
QSAR models for HEPT derivates as NNRTI inhibitors based on Monte Carlo method.
  • 48
  • PDF
Heme Oxygenase Inhibition by α‐(1H‐Imidazol‐1‐yl)‐ω‐phenylalkanes: Effect of Introduction of Heteroatoms in the Alkyl Linker
  • 13
Heme oxygenase-1 in tumors: is it a false friend?
  • 313
  • PDF
Pharmacological and Clinical Aspects of Heme Oxygenase
  • 948
  • PDF
...
1
2
3
4
5
...