Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.

@article{Intagliata2019HemeO,
  title={Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.},
  author={Sebastiano Intagliata and L. Salerno and Valeria Ciaffaglione and Carmen Leonardi and Antonino N Fallica and G. Carota and E. Amata and A. Marrazzo and V. Pittal{\`a} and G. Romeo},
  journal={European journal of medicinal chemistry},
  year={2019},
  volume={183},
  pages={
          111703
        }
}
Heme oxygenase (HO) enzymes are involved in heme catabolism and several physiological functions. Among the different HO isoforms, HO-2 stands out for its neuroprotective properties and modulatory activity in male reproduction. However, unlike the HO-1 ligands, the potential therapeutic applications of HO-2 inhibitors/activators have not been extensively explored yet. Moreover, the physiological role of HO-2 is still unclear, mostly due to the lack of highly selective HO-2 chemical probes. To… Expand
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