Heme Oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome

@article{Sheu2009HemeOM,
  title={Heme Oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome},
  author={Chau-Chyun Sheu and Rihong Zhai and Zhaoxi Wang and Michelle N. Gong and Paula Tejera and Feng Chen and Li Su and Boyd Taylor Thompson and David C. Christiani},
  journal={Intensive Care Medicine},
  year={2009},
  volume={35},
  pages={1343-1351}
}
Heme oxygenase-1 (HO-1) acts in cytoprotection against acute lung injury. The polymorphic (GT) n repeat in the HO-1 gene (HMOX1) promoter regulates HMOX1 expression. We investigated the associations of HMOX1 polymorphisms with acute respiratory distress syndrome (ARDS) risk and plasma HO-1 levels. Unmatched, nested case–control study. Academic medical center. Consecutive patients with ARDS risk factors upon ICU admission were prospectively enrolled. Cases were 437 Caucasians who developed ARDS… CONTINUE READING