Heme Oxygenase-1 Prevents Cardiac Dysfunction in Streptozotocin-Diabetic Mice by Reducing Inflammation, Oxidative Stress, Apoptosis and Enhancing Autophagy

@inproceedings{Zhao2013HemeOP,
  title={Heme Oxygenase-1 Prevents Cardiac Dysfunction in Streptozotocin-Diabetic Mice by Reducing Inflammation, Oxidative Stress, Apoptosis and Enhancing Autophagy},
  author={Yanli Zhao and Lina Zhang and Yu Qiao and Xiaoling Zhou and Guodong Wu and Lujing Wang and Yahui Peng and Xingli Dong and Hui Lian Huang and Lining Si and Xueying Zhang and Lei Zhang and Jihong Li and Wei Wang and Ling-Yun Zhou and Xu Gao},
  booktitle={PloS one},
  year={2013}
}
Heme oxygenase-1 (HO-1) has been implicated in cardiac dysfunction, oxidative stress, inflammation, apoptosis and autophagy associated with heart failure, and atherosclerosis, in addition to its recognized role in metabolic syndrome and diabetes. Numerous studies have presented contradictory findings about the role of HO-1 in diabetic cardiomyopathy (DCM). In this study, we explored the role of HO-1 in myocardial dysfunction, myofibril structure, oxidative stress, inflammation, apoptosis and… CONTINUE READING
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and apoptosis in the diabetic heart : New role of AMPK

  • VL Bodiga, Eda, S Bodiga
  • 2013

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